德孚医药出版社在国际纳米医学期刊发表了最新文章新型白蛋白纳米颗粒可增强二甲双胍的抗胰岛素抗性-肝癌活性，其内容摘要如下：
Introduction：
Metforminisanidealcandidatetotreatthelivertumorwithinsulinresistancebecauseofitsgoodperformanceinthetreatmentoftype2diabetesandtheadvantageincancertherapy.Weaimtodevelopadeliverysystemwithhigherefficiencythanfreedrug.
Methods：
Metformin-bovineserumalbumin(met-BSA)nanoparticles(NPs)werepreparedusingtheanti-solventprecipitationmethodwithastabilizerofBSAforparticlegrowth.Thetherapeuticeffectofthedrugwastestedbytheinsulin-resistantHepG2cellsandC57BL/6Jmiceataglucosestarvationcondition.TheinteractionmechanismofthedrugandtheproteinduringtheformationoftheNPswastestedusingaseriesofspectroscopy.
Results：
MetforminandBSAformednonporousandsphericalparticlesofaboutnmwithproperlognormaldistributionandthermostability.Thecellularuptake,aswellastheanti-livercanceractivitiesofmet-BSA,wasenhanceddramatically